2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154251
    2-Methoxy-9-β-D-ribofuranosyl-9H-purine
    2-Methoxy-9-β-D-ribofuranosyl-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Methoxy-9-β-D-ribofuranosyl-9H-purine
  • HY-152351
    8-Bromo-3’-deoxyguanosine
    8-Bromo-3’-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Bromo-3’-deoxyguanosine
  • HY-152813
    2′-Deoxy-2′-fluoro-4-deoxy-arabinouridine
    2′-Deoxy-2′-fluoro-4-deoxy-arabinouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2′-Deoxy-2′-fluoro-4-deoxy-arabinouridine
  • HY-152374
    3’-Deoxy-3’-fluoro-N6,N6-dimethyladenosine
    3’-Deoxy-3’-fluoro-N6,N6-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-3’-fluoro-N6,N6-dimethyladenosine
  • HY-154392
    2-Chloro-2’-deoxy inosine
    2-Chloro-2’-deoxy inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Chloro-2’-deoxy inosine
  • HY-154596
    2,6-Bis(4-morpholinyl)-9-b-D-ribofuranosyl-9H-purine
    2,6-Bis(4-morpholinyl)-9-b-D-ribofuranosyl-9H-purine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2,6-Bis(4-morpholinyl)-9-b-D-ribofuranosyl-9H-purine
  • HY-W725644
    L-2-Aminoadipate adenylate
    L-2-Aminoadipate adenylate is a nucleoside metabolite.
    L-2-Aminoadipate adenylate
  • HY-154371
    5’-O-Benzoyl-2’-O,4’-C-methyleneuridine
    5’-O-Benzoyl-2’-O,4’-C-methyleneuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-Benzoyl-2’-O,4’-C-methyleneuridine
  • HY-138616
    dGTP
    dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the precursors for DNA synthesis, and serves as a direct substrate for DNA replication and repair. dGTP is prone to oxidative damage; under the action of reactive oxygen species and other factors, dGTP is oxidized to form 8-oxo-dGTP.
    dGTP
  • HY-154533
    3’-O-Acetyl-2’-deoxyuridine
    3’-O-Acetyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-Acetyl-2’-deoxyuridine
  • HY-44220
    5-O-Benzoyl-1,2-di-O-isopropylidene-3-keto-alpha-D-xylofuranoside
    5-O-Benzoyl-1,2-di-O-isopropylidene-3-keto-alpha-D-xylofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-O-Benzoyl-1,2-di-O-isopropylidene-3-keto-alpha-D-xylofuranoside
  • HY-180724
    1-Carboxyvinyl carboxyphosphonate
    1-Carboxyvinyl carboxyphosphonate is a nucleoside metabolite.
    1-Carboxyvinyl carboxyphosphonate
  • HY-152835
    8-(Methylamino)adenosine
    8-(Methylamino)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    8-(Methylamino)adenosine
  • HY-154001
    2'-Deoxy-8-methylthioguanosine
    2'-Deoxy-8-methylthioguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2'-Deoxy-8-methylthioguanosine
  • HY-153060
    β-D-Ribofuranose analogue 1
    β-D-Ribofuranose analogue 1 is a nucleoside compound. β-D-Ribofuranose analogue 1 can be used for RNA synthesis.
    β-D-Ribofuranose analogue 1
  • HY-152480
    3’-O-(2-Methoxyethyl)-5-methylcytidine
    3’-O-(2-Methoxyethyl)-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    3’-O-(2-Methoxyethyl)-5-methylcytidine
  • HY-154356
    1-(alpha-L-Threofuranosyl)cytosine
    1-(alpha-L-Threofuranosyl)cytosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(alpha-L-Threofuranosyl)cytosine
  • HY-154160
    5-(2-Hydroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine
    5-(2-Hydroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-(2-Hydroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine
  • HY-152657
    N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine
    N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine
  • HY-152609
    N1-Cyanomethyl pseudouridine
    N1-Cyanomethyl pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Cyanomethyl pseudouridine